Epoxy curing agent News Chlopromazine hydrochloride

Chlopromazine hydrochloride

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Structural formula of chlorpromazine hydrochloride

Structural formula

Business number 01FJ
Molecular formula C17H20Cl2N2S
Molecular weight 355.34
label

2-Chloro-10-(3-dimethylaminopropyl)phenothiazine hydrochloride,

hibernation spirit,

Colagent,

Chlorpromazine,

aminazine,

chlorpromazine,

Chlorpromazine hydrochloride,

Hibernating phosphorus,

C17H19ClN2S·HCl

Numbering system

CAS number:69-09-0

MDL number:MFCD00012654

EINECS number:200-701-3

RTECS number:200-701-3

BRN number:3779989

PubChem number:24277891

Physical property data

1. Character:White or milky white crystalline powder, hygroscopic, slightly odorous, extremely bitter in taste, easily oxidized in air or Gradates to reddish brown in sunlight


2. Density (g/mL,25/4): Unsure


3. Relative vapor density (g/mL,AIR=1): Unsure


4. Melting point (ºC):179-180194-196 ).


5. Boiling point (ºC,Normal pressure): Uncertain


6. Boiling point (ºC, 5.2kPa): Unsure


7. Refractive index:Not sure


8. Flash point (ºC): Unsure


9. Specific optical rotation (º): Unsure


10. Autoignition point or ignition temperature (ºC): No��determined


11. Vapor pressure (kPa,25ºC): Unsure


12. Saturated vapor pressure (kPa,60ºC): Unsure


13. Heat of combustion (KJ/mol): Unsure


14. Critical temperature (ºC): Unsure


15. Critical pressure (KPa): Unsure


16. Oil and water (octanol/Log value of water) partition coefficient: Uncertain


17. Explosion limit (%,V/V): Unsure


18. Lower explosion limit (%,V/V): Unsure


19. Solubility:Easily soluble in water, ethanol, chloroform, insoluble in ether and benzene

Toxicological data

None

Ecological data

None

Molecular structure data

None

Compute chemical data

1. Reference value for hydrophobic parameter calculation (XlogP): None

2. Number of hydrogen bond donors: 1

3. Number of hydrogen bond acceptors: 3

4. Number of rotatable chemical bonds: 4

5. Number of tautomers: none

6. Topological molecule polar surface area 31.8

7. Number of heavy atoms: 22

8. Surface charge: 0

9. Complexity: 339

10. Isotopic origin�Quantity: 0

11. Determine the number of atomic stereocenters: 0

12. Uncertain number of atomic stereocenters: 0

13. Determine chemical bonds Number of stereocenters: 0

14. Number of stereocenters of uncertain chemical bonds: 0

15. Number of covalent bond units: 2

Properties and stability

None

Storage method

Keep it sealed and protected from light.

Synthesis method

By2-Chlorophenothiazine[92-39-7]Condensation and salt formation. 1.Condensation in reaction Add 2- Chlorophenothiazine and toluene, then add sodium hydroxide, stir and heat to reflux, remove moisture, and in 110℃ dripping1-Chlorine-3-Toluene solution of dimethylaminopropane, the reactant is decompressed to recover toluene to obtain chlorpromazine,C17H19CIN2S,[50-53-3]. 2.Salt Stir and heat chlorpromazine and isopropyl alcohol until 40℃, access dry hydrogen chloride to pH 4-5, and the chlorpromazine hydrochloride is obtained as a salt.

Purpose

has central stabilizing, antiemetic, anticonvulsant, anti- Adrenaline and other effects. Used to treat schizophrenia and mania. Anxiety disorders, mental disorders, nausea, vomiting, etc. It can also be used for artificial hibernation and low-temperature anesthesia.


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