Epoxy curing agent Knowledge L-phenylalanine strain fermentation technology_Kain Industrial Additives

L-phenylalanine strain fermentation technology_Kain Industrial Additives

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L-Phenylalanine is an optically active aromatic amino acid and one of the essential amino acids for the human body. It is also an important pharmaceutical and food chemical intermediate. In the food industry, L-phenylalanine is mainly used in sweeteners, flavorings and health products. L-phenylalanine and L-aspartic acid are condensed to form Aspartame (APM), which is about 200 times sweeter than sucrose, has low calorific value and is easily metabolized in the body, so it is suitable for obese patients and For diabetic patients. In recent years, the application of L-phenylalanine in the medical field has attracted more and more attention. L-phenylalanine prevents and treats osteoporosis drugs, heterocyclic dipeptide drugs that promote hormone release, thrombin inhibitors and endopeptidase inhibitors, and cardiovascular drugs.

Market prospects

Currently, the global annual demand for L-phenylalanine is approximately 38,000 tons, and is increasing year by year. The United States is the main consumer country, with annual consumption of more than 20,000 tons, accounting for about half of the world’s demand. L-phenylalanine is mainly used to synthesize the low-calorie, high-sweetness sweetener aspartame. The annual demand is about 18,000 tons, with an average annual growth rate of 10%-15%; on the other hand, L-phenylalanine The annual consumption of phenylalanine in the pharmaceutical industry is 7,000 tons, which has huge market application space.

Technical features

L-Tyrosine is widely used in medicine and chemistry. L-tyrosine is a precursor to many important secondary metabolites and an important precursor to the Parkinson’s disease drug 3,4-dihydroxy-L-phenylalanine (L-DOPA). Due to its long biosynthetic pathway and complex regulation, the use of microorganisms to produce L-tyrosine still faces many challenges.

In this project, a set of high-throughput screening technology for phenylalanine strains was independently developed, which can quickly and effectively screen strains with improved yields, and the screening efficiency can reach 106-107 clones/day.
During the implementation of the project, a high-yielding engineering strain was screened through a combination of rational transformation and high-throughput screening. After fermentation in a small-scale fermentation tank for 48 hours, the L-phenylalanine production reached 100g/L, and the conversion rate was 28%, reaching the industry-leading level, which can effectively reduce industrial production costs and bring greater market and benefits to enterprises.
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