Crospovidone (PVPP) is in strong demand in the pharmaceutical and food processing fields, and my country’s industry development faces challenges

Cross-linked polyvinylpyrrolidone (PVPP), also known as insoluble polyvinylpyrrolidone and cross-linked polyvinylpyrrolidone, refers to a high molecular water-insoluble polymer obtained by cross-linking reaction of N-vinyl 2-pyrrolidone. Crospovidone appears as white or off-white powder, has no special odor, and is insoluble in water and various solvents. Cross-linked povidone has the characteristics of good fluidity, easy processing, and high water absorption, and has broad application prospects in the fields of medicine and food processing.

The core raw material of cross-linked povidone is povidone (PVP). Povidone, also known as polyvinylpyrrolidone, is an N-vinyl amide polymer that can be produced by solution polymerization and bulk polymerization. my country is the world’s largest producer of povidone, accounting for 50% of the world’s total production capacity. However, at present, my country’s povidone companies focus on the production of mid-to-low-end products, while high-end products rely on imports, which brings certain challenges to the development of the cross-linked povidone industry.

The production process of cross-linked polyvinylpolypyrrolidone is relatively complex and the technical barriers to the industry are high. PVP cross-linking method, NVP monomer self-cross-linking polymerization method, NVP monomer and polyunsaturated compound copolymerization method, etc. are the main preparation methods of cross-linked polyvinylpolypyrrolidone. Cross-linked povidone prepared by different methods has differences in performance and cross-linking degree. Cross-linked povidone with high cross-linking degree can be prepared by using NVP monomer self-cross-linking polymerization method.

According to the “2023-2028 China Cross-linked Povidone (PVPP) Industry Market In-depth Research and Development Prospects Forecast Report span>》shows that crospovidone has excellent comprehensive properties and has broad application prospects in the fields of medicine and food processing. In the pharmaceutical field, crospovidone is used as a pharmaceutical excipient and can be used in the wet granulation and tableting process, dry granulation and tableting process and direct compression process of tablets; in the field of food processing, crospovidone is used as a pharmaceutical excipient. A filter aid that can effectively remove proteins and enzymes and can be used in vinegar and wine making processes. Benefiting from the accelerated development of downstream industries, the market demand for crospovidone is increasingly strong.

There are many crospovidone manufacturers in my country, mainly including New Kaiyuan Medical, Xingfa Group, Kelun Pharmaceutical, Shanhe Pharmaceutical, Bangsen New Materials, etc. Shanhe Pharmaceutical Excipients focuses on the research and development, production and sales of cross-linked povidone, soluble starch, microcrystalline cellulose, betacyclodextrin and other pharmaceutical excipients, and is a representative enterprise of cross-linked povidone in my country. At present, due to factors such as high technical barriers, my country’s cross-linked povidone industry is in overall supply situation and is highly dependent on product imports. This is the main challenge facing the development of the industry.

Industry analysts said that as a pharmaceutical excipient, crospovidone has strong market demand and good industry development prospects. However, currently, due to factors such as insufficient supply of raw materials and high technical barriers, my country’s high-end crospovidone production capacity is low and unable to meet downstream demand. In the future, as local companies continue to exert their efforts, the development speed of my country’s cross-linked polyvinylpolypyrrolidone industry is expected to further accelerate.