Background and overview[1]
2,5-Diaminotoluene dihydrochloride can be used as a pharmaceutical synthesis intermediate. If 2,5-diaminotoluene dihydrochloride is inhaled, move the patient to fresh air; if skin contact occurs, take off contaminated clothing, rinse the skin thoroughly with soap and water, and seek medical attention if you feel uncomfortable.
Apply[1]
2,5-Diaminotoluene dihydrochloride can be used as a pharmaceutical synthesis intermediate. If the following reaction occurs:
Add 2,5-diaminotoluene dihydrochloride (5.85g, 30mmol), triethylamine (6.34g, 63mmol), 2-naphthaldehyde (9.84g, 63mmol) and EtOH into a 300mL four-necked flask. (80g), DMSO (60g), and stir while heating to 80°C. After the reaction, the precipitate was filtered, washed with EtOH (80 mL), and dried to obtain 11.3 g of [T-14] (yellow solid) (yield: 94%). The results of 1H-NMR of the target substance are shown below. Based on the results, it was confirmed that the obtained solid was the target.
1HNMR (400MHz, CDCl3): δ8.69(s, 1H), 8.59(s, 1H), 8.18-8.25(m, 4H), 7.88-7.96(m, 6H), 7.52-7.58(m, 4H), 7.19-7.24(m, 2H), 7.08-7.10(d, 1H), 2.49(s, 3H)
In addition, 2,5-diaminotoluene dihydrochloride can also undergo the following reactions:
Add 2,5-diaminotoluene dihydrochloride (5.85g, 30mmol), triethylamine (6.34g, 63mmol), 4-biphenylcarbaldehyde (11.5g, 63mmol) and EtOH (80g) and DMSO (60g) were heated to 80°C with stirring. After the reaction, the precipitate was filtered, washed with EtOH (80 mL), and dried to obtain 12.7 g of [T-15] (yellow solid) (yield: 93%). The results of 1H-NMR of the target substance are shown below. From the results, it was confirmed that the obtained solid was the target [T-15].
1HNMR (400MHz, CDCl3): δ8.56 (s, 1H), 8.47 (s, 1H), 7.98-8.06 (t, 4H), 7.71-7.73 (d, 4H), 7.65-7.67 (d, 4H), 7.46-7.50(t, 4H), 7.38-7.41(t, 2H), 7.19(s, 1H), 7.14-7.16(d, 1H), 7.03-7.05(d, 1H), 2.45(s, 1H).
Main reference materials
[1] (CN107003577) A composition for manufacturing a liquid crystal aligning film for a transverse electric field driven liquid crystal display element, a liquid crystal aligning film using the composition and a manufacturing method thereof, and a liquid crystal display element having a liquid crystal aligning film and the same Manufacturing method
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