Various applications of disodium glycyrrhizate_Kain Industrial Additives

Background and overview^[1-2]

Disodium glycyrrhizinate is a white or light yellow powder with a very sweet taste and a special sweet aftertaste. Disodium glycyrrhizinate can be used as a sweetener for bean paste and soy sauce. The traditional preparation method of disodium glycyrrhizate is to crush licorice, extract it with water, concentrate it into a dark brown viscous liquid, and then refine it with dilute ethanol to obtain glycyrrhizic acid crystals. If necessary, activated carbon can be added for decolorization. Then it is converted into disodium salt to obtain the product disodium glycyrrhizinate. The disodium glycyrrhizinate obtained by this method not only has a low yield, but also has poor product quality. There are also methods that use monoammonium glycyrrhizinate as raw material and directly add sodium salt (sodium carbonate, sodium bicarbonate, sodium hydroxide) to react to obtain disodium glycyrrhizinate. There will be a problem of residual ammonium in the product.

Apply^[2-5]

Glycyrrhizic acid disodium salt is a natural food sweetener, which is extracted from the natural plant licorice and processed through a special process. The main ingredient is glycyrrhizic acid, which is 200-300 times sweeter than sucrose. It is very soluble in water. The solution is clear and transparent, has no impurities and strange smell, and has a good taste. In terms of food additives, it has low heat energy, safety, non-toxicity and strong It has medical and health care effects and is the most ideal sweetener for patients with hypertension, obesity, diabetes, and heart disease. It has a strong special flavor of licorice and has the functions of health care, detoxification, liver protection, anti-inflammation, and flavor enhancement. It is very ideal. Pure natural sweetener raw materials.

①In the food industry, it is used in canned meat, condiments, condiments, soy sauce, bean paste, salad dressing, pickled products, frozen desserts, chewing gum, betel nuts, bakery products, candies, biscuits, low-sugar foods, Sugar-free food, juice, dairy products, milk powder, functional drinks, etc.;

②The pharmaceutical industry is used for eye drops and ointments for stomatitis; for example, preparing a pharmaceutical preparation suitable for Duchenne muscular dystrophy: it consists of the active ingredients Eteplirsen, sodium chloride, disodium glycyrrhizinate, meglumine, pH Composed of regulator and water for injection.

The quality of the present invention is stable. After long-term accelerated testing, it is found that its appearance, pH value, visible foreign matter, insoluble particles and potency have not changed significantly. At the same time, after the present invention is compatible with 0.9% sodium chloride, it can After being left for a long time, the insoluble particles and potency have not changed significantly, which greatly facilitates clinical use and improves the safety of use by patients. For another example, it is used to prepare a cefixime dispersible tablet, which relates to the field of medical technology. The raw materials include: cefixime, polyoxyethylene (20) sorbitol monooleate (Tween 80), loquat dew, and glycyrrhizic acid. Disodium, aspartame phenylalanine methyl ester, alitame, xanthan gum, citric acid, pentaerythritol, sodium folded carboxymethyl starch; including the following steps: combine cefixime, disodium glycyrrhizinate, asparagine Phenylalanine methyl ester, alitame, and sodium folded carboxymethyl starch are subjected to ultrafine treatment until the particles are 200-250 mesh, sieved, and mixed evenly to obtain a mixture; add the remaining components to deionized water for ultrasonic treatment, microwave, Obtain a solution; add the mixture to the solution, microwave, add it to a high-efficiency wet granulator, granulate; dry and tablet. The surface area of the tablet of the present invention increases after being dispersed, which can promote the dissolution and absorption of the drug in the body and reduce the burden of the drug on the gastrointestinal tract. Easy to take, disperse with water before taking.

③The cosmetics industry is used for skin anti-inflammatory, antibacterial, cleansing, and improving skin health. It can be used in skin care lotions and facial creams;

④ Used in toothpaste in daily chemical industry.

Preparation^[2-3]

Method 1: A preparation method of glycyrrhizic acid disodium salt, the specific steps are as follows:

1) Weigh the monoammonium glycyrrhizinate salt, add solvent, and stir to dissolve at room temperature;

2) After dissolving, add cation exchange resin, stir at room temperature, filter, and retain the filtrate to obtain a converted solution of monoammonium glycyrrhizinate salt;

3) Add activated carbon to the converted solution of monoammonium glycyrrhizinate, stir to decolorize, filter, and retain the filtrate; add sodium salt to the filtrate, stir, concentrate to remove the solvent, filter, retain the filtrate, and spray-dry the filtrate, That is, the finished product of glycyrrhizic acid disodium salt is obtained.

Method 2: A method for preparing disodium glycyrrhizinate, including the following steps:

1) Refining of glycyrrhizic acid: 100g of crude glycyrrhizic acid with a content of 75% is added to 300mL.��Butanol, extract under reflux for 2.0h, pour out the extract, the residue is extracted with 200mL n-butanol under reflux for 1.5h, pour out the extract, and the residue is extracted with 100mL n-butanol under reflux for 1.0h. Combine the three extracts, add 3-5% (W/V) 3-5% (W/W) activated clay and 3-5% (W/W) diatomaceous earth, incubate under reflux for 30 minutes, filter. Concentrate the filtrate under reduced pressure to a specific gravity of 1.15-1.20, add a small amount of diethyl ether, stir thoroughly, let it stand, crystallize, and centrifuge. The crystallized product is vacuum dried at 60-70°C for 4-6 hours to obtain 71g of glycyrrhizic acid fine product. Content 99.5%.

2) Preparation of glycyrrhizic acid disodium salt: 80g of glycyrrhizic acid is dissolved by heating with 320mL of n-butanol, add sodium carbonate to adjust the pH to 6-7, heat under reflux for 3-4 hours, let stand, precipitate, and add 1- 3 times the amount of deionized and heated to dissolve, move to the alcohol precipitation tank, add 95% ethanol under stirring, mix thoroughly to make the alcohol content reach more than 80%, add solid sodium hydroxide to adjust the pH to 6-7, let it stand until the precipitation is complete, and then pump Filter, rinse the filter cake with absolute ethanol, and vacuum dry at 60-70°C for 4-6 hours to obtain 84g of glycyrrhizic acid disodium salt.