Propylene glycol is an organic compound (diol), usually slightly Sweet, odorless, colorless and transparent oily liquid, hygroscopic and easily mixed with water, acetone, and chloroform. Propylene glycol has a wide range of applications and is often used as a hygroscopic agent, antifreeze, lubricant and solvent in the food, pharmaceutical and cosmetic industries. Propylene glycol supply points out: Propylene glycol, which is widely used in various industries, is divided into two types: 1,2-propanediol and 1,3-propanediol. 1,2-Propylene glycol has good viscosity and hygroscopicity and is widely used in the food, pharmaceutical and cosmetic industries.
The medicinal properties and applications of propylene glycol are as follows:
Propylene glycol has good solubility, low toxicity and irritation, and is widely used Used as solvents and extraction solvents for injections (such as intramuscular injections, intravenous injections) and non-injection pharmaceutical preparations (such as oral liquids, ophthalmic preparations, otic preparations, dental preparations, rectovaginal preparations, transdermal preparations, etc.) And preservatives, it is a better solvent than glycerol and can dissolve many substances such as corticosteroids (sex hormones), chloramphenicol, sulfonamides, barbiturates, reserpine, quinidine, acetic acid dehydrogenation Corticosterone, ethyl fumarol sulfate, nitrogen mustard hydrochloride, vitamin A, vitamin D, many volatile oils, most alkaloids, and many local anesthetics.
As a bacteriostatic agent, propylene glycol is similar to ethanol. Its efficacy in inhibiting mold is similar to that of glycerin and slightly lower than that of ethanol. Propylene glycol is commonly used as a plasticizer in aqueous film coating materials. An equal-amount mixture with water can delay the hydrolysis of certain drugs and increase the stability of the preparation. 15% to 30% propylene glycol solutions and semi-solid preparations can be used as antibacterial preservatives, about 15% propylene glycol topical preparations can be used as moisturizers, 10% to 30% propylene glycol aerosol solvents, 10% to 25 % of propylene glycol oral solutions, 10% to 60% of injectable preparations, and 5% to 80% of topical preparations are used as solvents and co-solvents.
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