Anti-inflammatory and analgesic drug production drives 2-phenylpropionic acid market development

2-Phenylpropionic acid is also known as α-phenylpropionic acid, 2-phenylpropionic acid, DL phenylpropionic acid, DL-2-phenylpropionic acid, 2-PPA. The molecular formula is C9H10O2, and the CAS registration number is 492-37- 5. The molecular weight is 150.18 and the appearance is colorless to light yellow transparent liquid. 2-Phenylpropionic acid is an important intermediate that can be used in the synthesis of medicines, spices and pesticides. At present, 2-phenylpropionic acid is mainly used as a pharmaceutical intermediate for the synthesis of loxoprofen sodium API.

​ ​ 2-Phenylpropionic acid is a niche chemical product and is mainly used to synthesize arylpropionic acid anti-inflammatory and analgesic drugs. Judging from the degree of market development, the 2-phenylpropionic acid industry in developed countries such as Japan and South Korea developed earlier, with rich experience and technology accumulation, and the production and application of 2-phenylpropionic acid was earlier. In 1986, loxoprofen sodium synthesized by Daiichi Sankyo Co., Ltd. from 2-phenylpropionic acid was launched on the market. Entering the 21st century, with the development of arylpropionic acid products, 2-phenylpropionic acid has been increasingly used in the field of anti-inflammatory and analgesic drugs.

Due to product use and other factors, the market size of China’s 2-phenylpropionic acid industry is small. At the same time, affected by stricter environmental protection, some companies have withdrawn from the 2-phenylpropionic acid industry, resulting in fewer companies participating in production in the industry. Mainly manifested as competition among local enterprises, competition is relatively relaxed. At present, there are only two 2-phenylpropionic acid manufacturers in China, namely Henan Huashang Pharmaceutical Co., Ltd. and Changzhou Tianhua Pharmaceutical Co., Ltd. According to the released “2023-2027 China 2-Phenylpropionic Acid Market Monitoring and Future Development Prospects Research Report“, In 2022, China’s 2-phenylpropionic acid industry output will be less than 400 tons.

Among them, Henan Huashang Pharmaceutical Co., Ltd. is a domestic 2-phenylpropionic acid manufacturer with a long history of development and relatively complete production technology. It is a major player in the domestic 2-phenylpropionic acid market competition; Changzhou Tianhua Pharmaceutical Co., Ltd. The company has a short development time, and its large-scale production capacity and overall competitive strength are relatively weak.

In recent years, the national and local governments have issued policies such as the “Guidance Catalog for Industrial Structural Adjustment (2023 Edition)” and “Notice on the Implementation Plan for Promoting the High-Quality Development of Raw Material Source Industries” to guide the development of the fine chemical industry. For 2-phenylpropionic acid The sustainable and healthy development of the industry provides a good environment, which is conducive to the capital increase and production expansion of the 2-phenylpropionic acid industry.

2-Phenylpropionic acid can be used to synthesize loxoprofen sodium, which is an important 2-phenylpropionic acid non-steroidal analgesic and anti-inflammatory drug with significant analgesic, anti-inflammatory and antipyretic properties. Effect. Analysts believe that in the domestic market, loxoprofen sodium is available in capsules, ordinary tablets, granules and patches. 2 dosage forms have been approved for marketing; and every year, new pharmaceutical companies are engaged in the research and development and production of loxoprofen sodium. It is expected that the demand for 2-phenylpropionic acid products will maintain steady growth in the next few years.