2-Phenylpropionic acid has broad prospects but few companies

2-Phenylpropionic acid is also known as α-phenylpropionic acid, DL phenylpropionic acid, DL-2-phenylpropionic acid, and 2-PPA. Its molecular formula is C9H10O2, CAS registration number is 492-37-5, and its molecular weight is 150.18. Appearance Colorless to light yellow transparent liquid. 2-Phenylpropionic acid is the most important, basic and simplest structural 2-arylpropionic acid compound, and it is also a basic pharmaceutical intermediate for the synthesis of other 2-arylpropionic acid substances and drugs.

According to different raw materials, there are many synthesis methods of 2-phenylpropionic acid. At present, the main synthesis methods of 2-phenylpropionic acid in my country include styrene method, acetophenone method, styrene + sodium cyanide method, phenylacetonitrile + dimethyl carbonate Ester method/dimethyl sulfate, etc. Among them, the styrene method has the characteristics of simple process, easy availability of raw materials, green and environmental protection, etc. It obtains 2-phenylpropionaldehyde through hydroformylation reaction, and then uses oxidation method to obtain 2-phenylpropionic acid.

2-Phenylpropionic acid is an important intermediate that can be used in the synthesis of medicines, spices and pesticides. Currently, 2-phenylpropionic acid is mainly used as an intermediate for loxoprofen sodium. Loxoprofen sodium is a drug used to relieve fever, headache and general joint and muscle pain caused by acute upper respiratory tract infections and other diseases. It can also be used for rheumatoid arthritis, low back pain, frozen shoulder, shoulder, neck and wrist syndrome. Symptoms and anti-inflammatory analgesia after surgery, trauma, and tooth extraction. At present, the main manufacturers of loxoprofen sodium API in my country include Dijia Pharmaceutical Group Co., Ltd., Hunan Jiudian Hongyang Pharmaceutical Co., Ltd., Shandong Luoxin Pharmaceutical Group Heng Pharmaceutical Co., Ltd., etc.

In recent years, thanks to the expansion of the production scale of loxoprofen sodium in my country, the demand for 2-phenylpropionic acid has continued to expand. According to the “2023-2028 2-Phenylpropionic Acid Industry Market In-depth Research and Investment Prospect Forecast Analysis Report released by the Industrial Research Center It shows that China’s demand for 2-phenylpropionic acid in 2022 will be close to 500 tons.

The market capacity of 2-phenylpropionic acid is small and there are not many domestic companies. At the same time, affected by the tightening of environmental protection, some companies have withdrawn from the 2-phenylpropionic acid industry. At present, the main domestic 2-phenylpropionic acid production companies include Henan Huashang Pharmaceutical Co., Ltd., Changzhou Tianhua Pharmaceutical Co., Ltd., and Huashuo Technology Co., Ltd., etc.

Industry analysts said that the country currently issues special standards for the quality, performance, technology and other indicators of 2-phenylpropionic acid products. The lack of industry-related standards is not conducive to the healthy and sustainable development of the 2-phenylpropionic acid industry. The 2-phenylpropionic acid industry needs to establish a 2-phenylpropionic acid policy and standard system that is suitable for my country’s industrial characteristics and in line with international standards as soon as possible, and improve relevant standards such as 2-phenylpropionic acid requirements, production methods, and inspection methods as soon as possible to promote the standardization of the industry. , standardization direction development. In addition, as environmental protection policies become increasingly strict, 2-phenylpropionic acid production companies should increase investment in environmental protection. On the one hand, they should increase the purchase expenditure of environmental protection equipment, and on the other hand, they should actively develop greener production processes.