Trifluoroethyl acetate (TFAE) can be used to produce COVID-19 specific drugs. High-purity ethyl trifluoroacetate is its representative product.

Ethyl trifluoroacetate (TFAE), also known as ethyl trifluoroacetate, has a chemical formula of C4H5F3O2 and is an organic compound. Ethyl trifluoroacetate appears as a colorless and transparent liquid with a pungent odor. It is soluble in ether, chloroform and ethanol, and slightly soluble in water. Ethyl trifluoroacetate is corrosive, flammable, volatile, highly soluble and highly acidic, and is widely used in the fields of medicine, pesticides and organic synthesis.

Ethyl trifluoroacetate is a flammable liquid and belongs to Class III dangerous goods. During its production process, various parameters need to be strictly controlled to avoid leakage and explosion. The main synthesis method of ethyl trifluoroacetate is the reaction method between trifluoroacetic acid and ethanol. This method uses trifluoroacetic acid and ethanol as raw materials, reacts them at a certain temperature and pressure, then adds a catalyst, and undergoes reaction, separation, and purification. and other processes to obtain the finished product. In recent years, many chemical companies have continued to increase their research on the synthesis methods of ethyl trifluoroacetate. Emerging synthesis methods such as ultrasonic-assisted synthesis and microwave-assisted synthesis have gradually been widely used due to their advantages of low production cost and high yield.

High-purity ethyl trifluoroacetate is a high-end product of ethyl trifluoroacetate, with a purity of more than 99.5% and is widely used in the pharmaceutical field. As the COVID-19 epidemic continues to spread, the market demand for high-purity ethyl trifluoroacetate, as the raw material for COVID-19 specific drugs, continues to grow. The global high-purity ethyl trifluoroacetate market will reach 510 million yuan in 2022, a year-on-year growth of 9.3%. In the future, with in-depth research, the application scope of high-purity ethyl trifluoroacetate will be further expanded, which will lead to an increase in the prosperity of the ethyl trifluoroacetate industry.

According to the “2023-2028 China Trifluoroethyl Acetate (TFAE) Industry Market In-depth Research and Development Prospects Forecast Report span>》shows that as an organic chemical raw material, ethyl trifluoroacetate is widely used in the fields of medicine, pesticides, organic synthesis and other fields. In the early stages of industry development, due to factors such as high technical barriers, my country’s ethyl trifluoroacetate production capacity was low, and the industry as a whole was in short supply. In recent years, with the continued efforts of local companies and increasingly strong downstream demand, my country’s ethyl trifluoroacetate production capacity has continued to expand, output has further increased, and the development of the industry has accelerated.

Dayang Biotechnology and Sinochem Blue Sky are the representative enterprises of ethyl trifluoroacetate in my country. The above two companies focus on the research and development, production and sales of pharmaceutical-grade ethyl trifluoroacetate. In January 2022, Sinochem Blue Sky and Pfizer reached a cooperation to supply bulk pharmaceutical ingredients for the new coronavirus specific drug Paxlovid——Ethyl trifluoroacetate.

Industry analysts said that with the accelerated development of the COVID-19 specific drug industry, the application demand for ethyl trifluoroacetate has increased. In the early stages of industry development, my country’s high-purity ethyl trifluoroacetate was highly dependent on imports. In recent years, with the continued efforts of local enterprises, the localization process of my country’s high-purity ethyl trifluoroacetate market has continued to accelerate, which provides favorable conditions for the development of the ethyl trifluoroacetate industry.