With favorable national policies, the market demand for the new environmentally friendly pesticide azoxystrobin will continue to grow

Azoxystrobin is a β-methoxyacrylate natural fungicide isolated from mushrooms. It has the characteristics of high efficiency, broad spectrum, protection, treatment, and low toxicity. It is the second most popular fungicide in the global pesticide industry after triazole fungicides. Another new agricultural fungicide with great development potential and market vitality. Azoxystrobin has no cross-resistance with other currently existing fungicides and is used in a variety of crops. In cereals, azoxystrobin can effectively control powdery mildew, rust, blight, leaf spot and net spot.

As a typical representative of methoxyacrylate fungicides, pure azoxystrobin is a white crystalline solid, and the original drug is a brown solid. Its action point is Cyt b low potential energy heme binding at the Qo site on the outer wall of the inner mitochondrial membrane. The inhibitor interferes with the respiration of fungal cells by preventing ATP synthesis, thereby uniformly targeting the growth of pathogenic bacteria or killing them.

At present, there are two main synthesis routes for azoxystrobin technical material: the first one is to first synthesize the intermediate (E)-3-methoxy-2-(2-hydroxyphenyl)-methyl acrylate, and then combine it with 4 , 6-dichloropyrimidine and salicylonitrile react to form the final product; the other is that 4,6-dichloropyrimidine reacts with salicylonitrile first and then with compound (E)-3-methoxy-2-(2 -Hydroxyphenyl)-methyl acrylate should yield azoxystrobin. Among them, the synthesis of intermediate (E)-3-methoxy-2-(2-hydroxyphenyl)-methyl acrylate is the key to the synthesis of azoxystrobin.

Azoxystrobin was the first fungicide developed by Syngenta. Before 2010, due to patent protection, there was only one company in the world, Syngenta. After 2010, as the patent expired, global azoxystrobin production capacity expanded rapidly. China is a major pesticide producer with strong demand for pesticides. The number of companies in the domestic azoxystrobin industry has increased rapidly and production capacity has rapidly expanded, making it an important azoxystrobin producer in the world.

According to the“China’s Azoxystrobin Industry Market Supply and Demand Status and Development Trend Forecast Report 2022-2026” released by the Industrial Research Center, In 2021, China’s azoxystrobin market size will reach 26 billion yuan.

Industrial Research personnel said that at present, my country has become an important producer of azoxystrobin in the world, and domestically produced azoxystrobin has excellent cost performance. Export to foreign markets. In addition, azoxystrobin, as a blockbuster product of methoxyacrylates, with the gradual maturity of application technology, the promotion of compounding applications, and the support of national policies such as the development of environmentally friendly fungicides, the domestic market demand for azoxystrobin has increased. will grow further.