Pharmaceutical market development, 3-hydroxytetrahydrofuran industry development environment improved

3-Hydroxytetrahydrofuran is a fine chemical product with a molecular formula of C4H8O2, a molecular weight of 88.1051, and a density of 1.148g/cm3. It is irritating and can be divided into (S)-3-hydroxytetrahydrofuran and (R)-3-hydroxy based on chirality. Tetrahydrofuran, among which (S)-3-hydroxytetrahydrofuran is a common 3-hydroxytetrahydrofuran product on the market.

3-Hydroxytetrahydrofuran is an important pharmaceutical intermediate and is widely used in the synthesis of anti-cancer drugs, anti-diabetic drugs, anti-AIDS and other drugs. As a pharmaceutical intermediate, it can be used to synthesize afatinib (used to treat advanced non-small cell lung cancer and HER2-positive advanced breast cancer), empagliflozin (antidiabetic drug), amprenavir (drug for the treatment of AIDS), Fosamprenavir calcium (which can be used directly in the treatment of AIDS and is also a prodrug for the synthesis of amprenavir) and other medicines. In addition, 3-hydroxytetrahydrofuran can also be used to synthesize pesticides, which can improve the herbicidal activity and selectivity of diphenyl ether herbicides.

3-Hydroxytetrahydrofuran is mainly used in the fields of medicine and pesticides, especially in the pharmaceutical field, where its demand is relatively large. But overall, 3-hydroxytetrahydrofuran, as an intermediate, is used in relatively small amounts in its main applied drugs, and the production scale of its main applied drugs, such as afatinib, is relatively limited, resulting in a relatively small market capacity for 3-hydroxytetrahydrofuran. Small, it is not conducive to stimulating the production enthusiasm of 3-hydroxytetrahydrofuran. According to the released “China 3-hydroxytetrahydrofuran Industry Market Monitoring and Future Development Prospects Research Report 2022-2026“, 2021 In 2017, China’s demand for 3-hydroxytetrahydrofuran was only a few hundred tons. Many domestic 3-hydroxytetrahydrofuran manufacturers, such as Anmei Technology and Kangdexiang Pharmaceutical, have withdrawn from production due to small market capacity.

Due to the relatively small market capacity, it is difficult to support the large production scale of the 3-hydroxytetrahydrofuran industry. Therefore, most of the companies in the 3-hydroxytetrahydrofuran industry are small and medium-sized enterprises, and the production scale of each enterprise is mostly below the ton level and above the ton level. There are only a few enterprises such as Jiangsu Yutian Pharmaceutical Co., Ltd. Some companies are mostly laboratory-based and carry out customized development according to user orders, with production scales ranging from kilograms to hundreds of kilograms. The smaller production scale within the industry results in low industry competitiveness and low influence, which is not conducive to the long-term development of the industry.

Analysts believe that in the future, the market environment for 3-hydroxytetrahydrofuran is expected to continue to improve, and the demand for 3-hydroxytetrahydrofuran may be further released. The main reasons are: (1) The aging of the country has deepened, leading to an increase in patients with diabetes and cancer. At the same time, patients’ consumption power has increased, and the demand for new drugs has increased, which has promoted the increase in demand for 3-hydroxytetrahydrofuran; (2) Contains 3-hydroxytetrahydrofuran The development and gradual introduction of new drugs of tetrahydrofuran to the market will expand the application scope of 3-hydroxytetrahydrofuran; (3) the demand areas are further concentrated in the pharmaceutical field. As pesticide management measures become stricter, its demand in the pesticide field may gradually decrease .