VERTELLUS PC phosphorylcholine coating, implant-grade medical hydrophilic and ultra-slippery coating, polymer biomimetic coating, inhibits protein accumulation and reduces blood activation

Introduction to PC Technology
PC is the abbreviation of phosphorylcholine, which is present in a variety of phospholipids, especially in The chemical name for the polar head groups in the phospholipids that make up the bilayer structure of cell membranes.
PC Technology is a proprietary technology platform for methacrylic acid polymers containing phosphorylcholine. These biomimetic materials are built on the body's own chemistry, but they are entirely synthetic, allowing precise control of purity, molecular structure, and avoiding the risks associated with animal-derived ingredients. They can provide a simple and effective solution to the biochemistry challenges faced by medical devices and can be tailored to specific application needs.

Product List
Ventrus Biomaterials offers a wide range of polymer coatings and monolithic materials to utilize PC Various features and benefits it can provide:

Polymer

Brief description

Application

PC1036

Standard Cross-linkedPCcoatings, highly durable drug delivery matrix span>

BiodivYsio ® Dexamet® TriMaxx™, Endeavor®Bracket

PC1059

Standard The non-cross-linkedPC coating is stabilized by hydrophobic surface interactions

Director Silk,CPBSystem

PC2118

lianPC<span style="font-fam�� and surfactant properties have potential benefits in non-medical applications.
The following summarizes some examples of applicable features, benefits, and potential applications:

Performance	Advantages	Potential application areas
Reduce Protein attachment	Reduce Scaling; easier to clean	Food and beverage processing equipment; pharmaceutical processing equipment
Reduce Protein attachment	Reduce Use of high-intensity cleaning chemicals	None Toxic marine anti-pollution
Reduce Bacterial adhesion and biofilm formation	Same as above , while reducing infection/pollution/Risk of spoilage	Use Keep clean in the hospital/Easy-to-clean surface; water filtration system; latex
Dear Water-based and moisturizing	Enhance Moisturizing and conditioning	Cosmetics ;Functional/Active textiles
Delivery Active substances	Active Materials and the above advantages	Cosmetics ;Health products

Application of PC Technology™ in Drug Delivery
In recent years, the development of drug-device combination products has brought about changes in some parts of the medical device field. Significant changes. Perhaps the most obvious example has always been the drug-eluting stents (DES) market, which has experienced explosive growth from $1.5 billion to $5 billion in two years. PC coating plays an important role in this field. Abbott's PC dexamethasone stent, Dexamet®, the second DES to be marketed in Europe, and Medtronic's PC-coated otralimus-eluting Endeavor® DES system, were notable in a two-year follow-up of 1,300 patients. During the trial, there was no case of late frame thrombosis. These application examples highlight the value of PC materials to the medical device market.
The flexible chemistry of PC polymers makes it possible to modify a variety of monomers, allowing the polymer to be tailored to different active substances and fine-tuning drug elution properties. Breakthrough drug-device combinations that demonstrate clinical benefits through controlled drug release, Ventrus' expertise is well suited to serve the development and commercialization of combination products.

PC coating can:
o Adsorption of high molecular weight compounds
o Absorption of low molecular weight drugs
o Demonstrate precise drug content and controlled release
o Once the drug is released, it remains stable

PC coating can deliver:
o Anti-inflammatories o Analgesics
o Antibacterial drugs o Hormones
o DNA fragments used in gene therapy

Activities that have been studied Specific examples of substances:
o Dexamethasone o Estradiol
o Paclitaxel o Sirolimus
o Bamastat o Angiopep
o Dipyridamole

Manufacturer information
Headquarters and The Applications Laboratory is located in Hampshire, UK. The division is part of Vertruth Specialty Products UK Ltd., based in the north of England, and the company operates under an ISO9001:2008 quality management system certification (certificate number FM02222). Vertex Specialty Products UK Ltd has facilities to produce multi-tonne PC materials and has recently opened a new polymer chemistry R&D laboratory to support its biomaterials division operations. Ventrus is ideally suited to assist medical supply companies in applying the benefits of PC technology to address unmet clinical needs and provide value-added, differentiated products.

Perhaps the most obvious example has always been the drug-eluting stent (DES) market, which has experienced explosive growth from $1.5 billion to $5 billion in two years. PC coating plays an important role in this field. Abbott's PC dexamethasone stent, Dexamet®, the second DES to be marketed in Europe, and Medtronic's PC-coated otralimus-eluting Endeavor® DES system, were notable in a two-year follow-up of 1,300 patients. During the trial, there was no case of late frame thrombosis. These application examples highlight the value of PC materials to the medical device market.
The flexible chemistry of PC polymers makes it possible to modify a variety of monomers, allowing the polymer to be tailored to different active substances and fine-tuning drug elution properties. Breakthrough drug-device combinations that demonstrate clinical benefits through controlled drug release, Ventrus' expertise is well suited to serve the development and commercialization of combination products.

PC coating can deliver:
o Anti-inflammatories o Analgesics
o Antibacterial drugs o Hormones
o DNA fragments used in gene therapy

Activities that have been studied Specific examples of substances:
o Dexamethasone o Estradiol
o Paclitaxel o Sirolimus
o Bamastat o Angiopep
o Dipyridamole

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