Epoxy curing agent Knowledge Chlorthalidone Chlorthalidone

Chlorthalidone Chlorthalidone

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Chlorthalidone structural formula

Structural formula

Business number 01LQ
Molecular formula C14H11ClN2O4S
Molecular weight 338.77
label

2-Chloro-5-(2,3-dihydro-1-hydroxy-3-oxo-1H-isoindol-1-yl)benzenesulfonamide,

1-Oxo-3-(4′-chloro-3′-sulphamoylphenyl)-3-hydroxyisoindoline,

1-Keto-3-(3′-sulfamyl-4′-chlorophenyl)-3-hydroxyisoindoline,

3-Hydroxy-3-(4-chloro-3-sulfamylphenyl)phthalimidine,

Chlorphthalidolone

Numbering system

CAS number:77-36-1

MDL number:MFCD00036257

EINECS number:201-022-5

RTECS number:DB1556000

BRN number:None

PubChem number:24892527

Physical property data

1. Appearance: white crystalline powder.


2. Density (g/mL,25/4℃): Unsure


3. Relative vapor density ( g/mL,Air =1): No OK


4. Melting point (ºC):: 224-226


5. Boiling point (ºC,Normal pressure): Uncertain


6. Boiling point (ºC,5.2kPa): Unsure


7. Refractive index: Uncertain


8. Flash Point (ºC): Unsure


9. Specific optical rotation (º): Unsure


10. Autoignition point or ignition temperature (ºC): Unsure


11. Vapor pressure (kPa,25ºC): Unsure


12. Molar volume (m3/mol ): 211.5


3. isotonic specific volume (90.2K):617.7


4. Surface Tension (dyne/cm):72.7


5. Polarizability10-24cm3): 32.20

Compute chemical data

1. Reference value for hydrophobic parameter calculation (XlogP): 0.9

2. Number of hydrogen bond donors: 3

3. Number of hydrogen bond acceptors: 5

4. Number of rotatable chemical bonds: 2

5. Number of tautomers: 2

6. Topological molecule polar surface area 118

7. Number of heavy atoms: 22

8. Surface charge: 0

9. Complexity: 564

10. Number of isotope atoms: 0

11. Determine the number of atomic stereocenters: 0

12. Uncertain number of atomic stereocenters: 1

13. Determine the number of chemical bond stereocenters: 0

14. Number of uncertain chemical bond stereocenters: 0

15. Number of covalent bond units: 1

Properties and stability

None yet

Storage method

this The product should be sealed and stored in a cool place.

Synthesis method

By Phthalic anhydride and chlorobenzene are added, nitrated and reduced to obtain phthalic anhydride (3-Amino– 4-Chlorobenzoyl) benzoic acid, then diazotization, displacement, chlorosulfonation, and finally cyclization and amination.

Purpose

Applicable For cardiac, renal, hepatic and other edema diseases, combined use with antihypertensive drugs can increase the efficacy. The preparation is a tablet.

amily: ‘Times New Roman’; mso-hansi-font-family: ‘Times New Roman'”>amino-4-chlorobenzoyl)benzoic acid, then diazotization, displacement, chlorosulfonation, and finally cyclization and amination.

Purpose

Applicable For cardiac, renal, hepatic and other edema diseases, combined use with antihypertensive drugs can increase the efficacy. The preparation is a tablet.

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