Epoxy curing agent Knowledge L-Leucine L-Leucine

L-Leucine L-Leucine

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L-leucine structural formula

Structural formula

Business number 01C4
Molecular formula C6H13NO2
Molecular weight 131.17
label

L-2-amino-4-methylpentanoic acid,

L-Leucine,

L-α-aminoisobutylacetic acid,

L-α-Aminoisocaproic acid,

(S)-2-Isohexanine,

(S)-2-Amino-4-methylpentanoic acid,

L-Leucine,

(s)-(+)-Leucine,

amino acid drugs,

intermediates,

Biochemical reagents

Numbering system

CAS number:61-90-5

MDL number:MFCD00002617

EINECS number:200-522-0

RTECS number:OH2850000

BRN number:1721722

PubChem number:24896510

Physical property data

1. Properties: White shiny hexahedral crystals or white crystalline powder

2. Density (g/mL, 25/4℃): 1.293

3. Relative steam Density (g/mL, air=1): Uncertain

4. Melting point (ºC): 293(lit.)

5. Boiling point (ºC, normal pressure): Unknown Confirm

6. Boiling point (ºC, 5.2kPa): Uncertain

7. Refractive index: Uncertain

8. Flash point (ºC): 145 -148

9. Specific rotation (º): 15.4 º (c=4, 6N HCl)

10. Autoignition point or ignition temperature (ºC): Uncertain

11. Vapor pressure (kPa, 25ºC): Uncertain

12. Saturated vapor pressure (kPa, 60ºC): Uncertain

13. Heat of combustion ( KJ/mol): Uncertain

14. Critical temperature (ºC): Uncertain

15. Critical pressure (KPa): Uncertain

16. Log value of oil-water (octanol/water) partition coefficient: Uncertain

17. Explosion upper limit (%, V/V): Uncertain

18. Explosion lower limit (%, V/V): Uncertain

19. Solubility: In the presence of hydrocarbons, it has stable performance in inorganic acid aqueous solutions. Each g is dissolved in about 40ml of water and about 100ml of acetic acid. Slightly soluble in ethanol (0.07%), soluble in dilute hydrochloric acid and alkaline hydroxide and carbonate solutions. Insoluble in ether

Toxicological data

Acute toxicity: rat intraperitoneal LD50: 5379 mg/kg; rabbit subcutaneous injection LDLo: 2620 mg/kg; mutagenicity: human lymphocyte Sister chromatid exchangeTEST SYSTEM: 10ml/L; breeding: rat oral TDLo: 138 gm/kgSEX /DURATION: female 5-15 days(s) after conception;

Rat intraperitoneal TDLo: 90 mg/kgSEX/DURATION: female 1-6 day(s) after conception

Ecological data

None yet

Molecular structure data

1. Molar refractive index: 34.86

2. Molar volume (cm3/mol): 126.6

3. Isotonic specific volume (90.2K): 316.4

4. Surface tension (dyne/cm): 39.0

5. Polarizability (10-24cm3): 13.82

Compute chemical data

1. Reference value for hydrophobic parameter calculation (XlogP): None

2. Number of hydrogen bond donors: 2

3. Number of hydrogen bond acceptors: 3

4. Number of rotatable chemical bonds: 3

5. Number of tautomers: none

6. Topological molecule polar surface area 63.3

7. Number of heavy atoms: 9

8. Surface charge: 0

9. Complexity: 101

10. Number of isotope atoms: 0

11. Determine the number of atomic stereocenters: 1

12. Uncertain number of atomic stereocenters: 0

13. Determine the number of chemical bond stereocenters: 0

14. Number of uncertain chemical bond stereocenters: 0

15. Number of covalent bond units: 1

Properties and stability

1. Exists in flue-cured tobacco leaves, burley tobacco leaves, and smoke.

2. There are three isomers: left-handed body, right-handed body and racemate.

Storage method

This product should be sealed, dry and protected from light.

Synthesis method

1. Protein (casein, keratin, etc.) is hydrolyzed with hydrochloric acid or dilute sulfuric acid. The hydrolyzate is neutralized with alkali to precipitate a mixture of leucine, L-isoleucine and L-methionine. Use the copper salt method Refined, and used β-naphthalenesulfonic acid to precipitate L-leucine to obtain pure product.

2.Extraction method

3.Fermentation method

4. Enzyme method

5. Tobacco: BU, 22; FC, 21. It is obtained by hydrolyzing and refining proteins such as gluten and corn protein. It can also be synthesized chemically.

Purpose

1. It is an essential amino acid. Adult men require 2.2g/d. It is necessary for normal growth of infants and maintenance of normal nitrogen balance for adults. This product is used as a nutritional supplement to prepare amino acid infusions and comprehensive amino acid preparations, hypoglycemic agents, and plant growth promoters. According to my country’s GB 2760-86 regulations, this product can be used as a spice.

2.As amino acid infusion and comprehensive amino acid preparation. For the diagnosis and treatment of idiopathic hyperglycemia in young children. It is also suitable for glucose metabolism disorders, liver disease with
reduced bile secretion, anemia, poisoning, muscular atrophy, sequelae of poliomyelitis, neuritis and mental illness.

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