Epoxy curing agent Knowledge Dichlorophenamide Dichlorophenamide

Dichlorophenamide Dichlorophenamide

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Diclofenac Sulfonamide Structural Formula

Structural formula

Business number 03D3
Molecular formula C6H6Cl2N2O4S2
Molecular weight 305.16
label

4,5-dichlorobenzene-1,3-disulfonamide,

Dichlorosulfonamide,

dichlorphenamide,

Bischlorosulfonamide,

1,3-Benzenedisulfonamide, 4,5-dichloro-,

1,3-disulfamoyl-4,5-dichlorobenzene,

1,3-Disulfamyl-4,5-dichlorobenzene,

3,4-Dichloro-5-sulfamylbenzenesulfonamide,

4,5-Dichloro-1,3-benzenedisulfonamide,

4,5-Dichloro-1,3-disulfamoylbenzene,

4,5-dichloro-3-benzenedisulf,

Heterocyclic compounds

Numbering system

CAS number:120-97-8

MDL number:MFCD00148948

EINECS number:204-440-6

RTECS number:CZ9200000

BRN number:None

PubChem ID:None

Physical property data

1. Character:White or nearly white crystalline powder


2. Melting point ():239~241

Toxicological data

1, acute toxicity data: Rat oral LD50: 10070mg/kg


Rat peritoneal cavityLD50:1244mg/kg


Mouse oral LD50: 1710mg/kg


Mouse peritoneal cavityLD50:304mg/kg


small Mouse intravenous injectionLD50643mg/kg


Dog intravenous injection LD50: 200mg/kg


2, reproductive toxicity data: Rat (female) oral TDLO: 4642mg/kg/1-22D


Mouse(女)经Peritoneal cavityTDLO500mg/kg/10D


Mouse(Female) Subcutaneous TDLO: 96mg/kg/15D


Mouse(Female) Gastrointestinal TDLO: 144mg/kg/13D

Ecological data

None

Molecular structure data


5. Molecular property data:


1. Molar refractive index: 61.28


2. Molar volumem3/ mol171.2


3. isotonic ratio90.2K494.9


Mouse(female) subcutaneously TDLO: 96mg/kg/15D


Mouse(Female) Gastrointestinal TDLO: 144mg/kg/13D

Ecological data

None

Molecular structure data


5. Molecular property data:


1. Molar refractive index: 61.28


2. Molar volumem3/ mol171.2


3. isotonic ratio90.2K494.9


4. Surface Tensiondyne/cm69.7


5. Dielectric constant:


6. Dipole moment10 -24cm3)


7. Polarizability: 24.29

Compute chemical data

1. Reference value for hydrophobic parameter calculation (XlogP): 0.3

2. Number of hydrogen bond donors: 2

3. Number of hydrogen bond acceptors: 6

4. Number of rotatable chemical bonds: 2

5. Number of tautomers: none

6. Topological molecule polar surface area 137

7. Number of heavy atoms: 16

8. Surface charge: 0

9. Complexity: 452

10. Number of isotope atoms: 0

11. Determine the number of atomic stereocenters: 0

12. Uncertain number of atomic stereocenters: 0

13. Determine the number of chemical bond stereocenters: 0

14. Number of uncertain chemical bond stereocenters: 0

15. Number of covalent bond units: 1

Properties and stability

1. Basic properties


White or nearly white crystalline powder. Melting point 239-241℃. Soluble in ethanol, easily soluble in alkaline solution, almost insoluble in water or chloroform. Odorless, slightly bitter taste.

Storage method

None

Synthesis method

2. Brief description of production method

Obtained from chlorosulfonation and amination of o-dichlorobenzene

Purpose

3. Purpose


This product is an inhibitor of carbonic anhydrase and has the effects of lowering intraocular pressure and diuresis. However, the diuretic effect is very weak and is mainly used to treat glaucoma to reduce intraocular pressure

p-alt: auto; mso-margin-bottom-alt: auto” align=left>4. Surface Tensiondyne/cm69.7


5. Dielectric constant:


6. Dipole moment10 -24cm3)


7. Polarizability: 24.29

Compute chemical data

1. Reference value for hydrophobic parameter calculation (XlogP): 0.3

2. Number of hydrogen bond donors: 2

3. Number of hydrogen bond acceptors: 6

4. Number of rotatable chemical bonds: 2

5. Number of tautomers: none

6. Topological molecule polar surface area 137

7. Number of heavy atoms: 16

8. Surface charge: 0

9. Complexity: 452

10. Number of isotope atoms: 0

11. Determine the number of atomic stereocenters: 0

12. Uncertain number of atomic stereocenters: 0

13. Determine the number of chemical bond stereocenters: 0

14. Number of uncertain chemical bond stereocenters: 0

15. Number of covalent bond units: 1

Properties and stability

1. Basic properties


White or nearly white crystalline powder. Melting point 239-241℃. Soluble in ethanol, easily soluble in alkaline solution, almost insoluble in water or chloroform. Odorless, slightly bitter taste.

Storage method

None

Synthesis method

2. Brief description of production method

Obtained from chlorosulfonation and amination of o-dichlorobenzene

Purpose

3. Purpose


This product is an inhibitor of carbonic anhydrase and has the effects of lowering intraocular pressure and diuresis. However, the diuretic effect is very weak and is mainly used to treat glaucoma to reduce intraocular pressure

�It is an inhibitor of carbonic anhydrase and has the effects of reducing intraocular pressure and diuresis. However, the diuretic effect is very weak and is mainly used to treat glaucoma to reduce intraocular pressure

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