Phthalosulfonamide

Structural formula

Business number	03N6
Molecular formula	C16H14N2O6S
Molecular weight	362.36
label	2-([(4-([Acetylamino]sulfonyl)phenyl)amino]carbonyl)benzoic acid, aromatic compounds

• Numbering system
• Physical property data
• Toxicological data
• Ecological data
• Molecular structure data
• Computing chemical data
• More
  • Properties and Stability
  • Storage method
  • Synthesis method
  • Purpose

Numbering system

CAS number:131-69-1

MDL number:MFCD00020275

EINECS number:205-035-7

RTECS number:None

BRN number:None

PubChem number:24898195

Physical property data

1. Characteristics: white crystalline powder, slightly odorous and slightly sour

2. Melting point (℃):186~202℃（ Decomposition)

3. Solubility:Very slightly soluble in water, slightly soluble in ethanol, soluble in acetone, easily soluble in hydrogen oxide Sodium solution.

Toxicological data

None yet

Ecological data

None yet

Molecular structure data

5. Molecular property data:

1、 Moore Refractive index: 87.97

2、 Moore Volume (m³/mol):245.0

3、 Isotonic specific volume (90.2K) ：702.8

4、 Surface Tension (dyne/cm):67.6

5、 Polarizability (10^-24cm³):34.87

Compute chemical data

1. Reference value for hydrophobic parameter calculation (XlogP): 1

2. Number of hydrogen bond donors: 3

3. Number of hydrogen bond acceptors: 6

4. Number of rotatable chemical bonds: 5

5. Number of tautomers: 4

6. Topological molecule polar surface area 138

7. Number of heavy atoms: 25

8. Surface charge: 0

9. Complexity: 619

10. Number of isotope atoms: 0

11. Determine the number of atomic stereocenters: 0

12. Uncertain number of atomic stereocenters: 0

13. Determine the number of chemical bond stereocenters: 0

14. Number of uncertain chemical bond stereocenters: 0

15. Number of covalent bond units: 1

Properties and stability

None yet

Storage method

None yet

Synthesis method

Introduction to production methods

Prepared from the acylation of p-aminobenzene sulfonacetamide and phthalic anhydride.

Purpose

Usage

<SPAN style="FONT-SIZE: 10pt; COLOR: #333333; FONT-FAMILY: Song�0.2K):702.8

4、 Surface Tension (dyne/cm):67.6

5、 Polarizability (10^-24cm³):34.87

Compute chemical data

1. Reference value for hydrophobic parameter calculation (XlogP): 1

2. Number of hydrogen bond donors: 3

3. Number of hydrogen bond acceptors: 6

4. Number of rotatable chemical bonds: 5

5. Number of tautomers: 4

6. Topological molecule polar surface area 138

7. Number of heavy atoms: 25

8. Surface charge: 0

9. Complexity: 619

10. Number of isotope atoms: 0

11. Determine the number of atomic stereocenters: 0

12. Uncertain number of atomic stereocenters: 0

13. Determine the number of chemical bond stereocenters: 0

14. Number of uncertain chemical bond stereocenters: 0

15. Number of covalent bond units: 1

Properties and stability

None yet

Storage method

None yet

Synthesis method

Introduction to production methods

Prepared from the acylation of p-aminobenzene sulfonacetamide and phthalic anhydride.

Purpose

Usage

This product is a sulfonamide drug. After oral administration, it slowly decomposes in the intestine to release sulfonamide acetyl, which produces intestinal antibacterial effects. It is clinically used for bacillary dysentery, enteritis and preparation before intestinal surgery. The efficacy is not as good as phthalosulfathiazole, but the absorption is stronger than phthalothiazolin.

��; mso-ascii-font-family: ‘Times New Roman’; mso-hansi-font-family: ‘Times New Roman'”>This product is a sulfonamide drug. After oral administration, it slowly decomposes in the intestine to release sulfonamide acetate. acyl to produce intestinal antibacterial effect. It is clinically used for bacillary dysentery, enteritis and preparation before intestinal surgery. The efficacy is not as good as phthalosulfathiazole, but the absorption is stronger than phthalosulfathiazole.