Epoxy curing agent Knowledge 2-phenyl-4-quinolinecarboxylic acid

2-phenyl-4-quinolinecarboxylic acid

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2-Phenyl-4-quinolinecarboxylic acid structural formula

Structural formula

Business number 03NK
Molecular formula C16H11NO2
Molecular weight 249.28
label

2-Phenylcinchoninic acid,

Cinchophen,

aromatic compounds

Numbering system

CAS number:132-60-5

MDL number:MFCD00006750

EINECS number:205-067-1

RTECS number:GD4025000

BRN number:192803

PubChem number:24851762

Physical property data

None yet

Toxicological data

Acute toxicity data:


Human oral LDLo: 214mg/kg


The man’s path is unknownLDLo: 74mg/kg


Rat orally LDLo500mg/kg


Mice orally LDLo1500mg/kg


Mouse abdominal cavityLD50: 200mg/kg


Mouse subcutaneous LD50: 350mg/kg


The path of the rabbit is unknownLDLo: 500mg/kg


Other multi-dose data:


Rat Sutra 口TDLo2800mg/kg/7D-I

Ecological data

None yet

Molecular structure data


5. Molecular property data:


1 Molar refractive index:73.70


2 Molar volume(m3/mol) :194.5


3 Isotonic specific volume90.2K):540.7


4 Surface tension(3.0 dyne/cm):59.6


5 Polarizability0.5 10-24 cm3):29.22


Compute chemical data

1. Reference value for hydrophobic parameter calculation (XlogP): 3.4

2. Number of hydrogen bond donors: 1

3. Number of hydrogen bond acceptors: 3

4. Number of rotatable chemical bonds: 2

5. Number of tautomers: none

6. Topological molecule polar surface area 50.2

7. Number of heavy atoms: 19

8. Surface charge: 0

9. Complexity: 325

10. Number of isotope atoms: 0

11. Determine the number of atomic stereocenters: 0

12. Uncertain number of atomic stereocenters: 0

13. Determine the number of chemical bond stereocenters: 0

14. Number of uncertain chemical bond stereocenters: 0

15. Number of covalent bond units: 1

Properties and stability

basic properties

White or light yellow crystalline powder. Pink point 213-216℃. 1g of this product is soluble in about 400ml of chloroform; 100ml of ether; 120ml of ethanol, and is almost insoluble in water. It tastes slightly bitter and almost odorless. It is easy to change when exposed to sunlight.

Storage method

None yet

Synthesis method

Brief description of production methods

Isatin is prepared into a sodium salt, which is ring-opened to form sodium anthranilate, and then cyclized with acetophenone to obtain cinchofen sodium, which can be acidified with acetic acid or hydrochloric acid to obtain cinchofen

Purpose

Purpose

Antipyretics and analgesics. Used for acute and chronic arthritis, rheumatic pain, neuralgia, low back pain, gout, headache, etc.

SIZE: 9pt; FONT-FAMILY: Arial; mso-font-kerning: 0pt”>3.0 dyne/cm):59.6


5 Polarizability0.5 10-24 cm3):29.22


Compute chemical data

1. Reference value for hydrophobic parameter calculation (XlogP): 3.4

2. Number of hydrogen bond donors: 1

3. Number of hydrogen bond acceptors: 3

4. Number of rotatable chemical bonds: 2

5. Number of tautomers: none

6. Topological molecule polar surface area 50.2

7. Number of heavy atoms: 19

8. Surface charge: 0

9. Complexity: 325

10. Number of isotope atoms: 0

11. Determine the number of atomic stereocenters: 0

12. Uncertain number of atomic stereocenters: 0

13. Determine the number of chemical bond stereocenters: 0

14. Number of uncertain chemical bond stereocenters: 0

15. Number of covalent bond units: 1

Properties and stability

basic properties

White or light yellow crystalline powder. Pink point 213-216℃. 1g of this product is soluble in about 400ml of chloroform; 100ml of ether; 120ml of ethanol, and is almost insoluble in water. It tastes slightly bitter and almost odorless. It is easy to change when exposed to sunlight.

Storage method

None yet

Synthesis method

Brief description of production methods

Isatin is prepared into a sodium salt, which is ring-opened to form sodium anthranilate, and then cyclized with acetophenone to obtain cinchofen sodium, which can be acidified with acetic acid or hydrochloric acid to obtain cinchofen

Purpose

Purpose

Antipyretics and analgesics. Used for acute and chronic arthritis, rheumatic pain, neuralgia, low back pain, gout, headache, etc.

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