Epoxy curing agent Knowledge Pilocarpine nitrate

Pilocarpine nitrate

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Structural formula of pilocarpine nitrate

Structural formula

Business number 03XH
Molecular formula C11H16N2O2·HNO3
Molecular weight 271.27
label

Pilocarpine nitrate,

(3S,4R)-3-Ethyldihydro-4-[(1-methyl-1H-imidazol-5-yl)methyl]-2(3H)-furanone nitrate,

3-Ethyldihydro-4-[(1-methyl-1h-imidazol-5-yl)methyl]-2(3h)-furanon(3s-cis)

Numbering system

CAS number:148-72-1

MDL number:MFCD00078497

EINECS number:205-723-7

RTECS number:TK1455000

BRN number:None

PubChem number:24898116

Physical property data

1. Physical property data:


1.Character: Colorless crystal or white shiny crystalline powder. Odorless. Bitter taste. No change when exposed to air, but easily deteriorates when exposed to light.


2.Melting point: 174~178℃.


3.Solubility:Easily soluble in water, the aqueous solution shows a weak acidic reaction. Slightly soluble in ethanol. Insoluble in ether or chloroform.


Toxicological data

2. Toxicological data:


1, acute toxicity: mouse intravenous LD50: 345 mg/kg;


Rat oral LD50: 911 mg/kg


2. Reproductive toxicity: Rat subcutaneous TDLo: 2200 mg/kg

Ecological data

3. Ecological data:


Other harmful Effect: This substance may be harmful to the environment, and special attention should be paid to water bodies.

Molecular structure data

Compute chemical data

4. Calculated chemical data:


1. Hydrogen Bonding Number of donors: 1


2. Hydrogen Bonding Number of receptors: 6


3. Rotatable Number of chemical bonds: 3


4. Topological molecules Polar surface area (TPSA):108


5. Heavy atoms Quantity: 19


6. Surface charge :0


7. Complexity :270


8.2. Number of hydrogen bond acceptors:6


3. Rotatable Number of chemical bonds: 3


4. Topological molecules Polar surface area (TPSA):108


5. Heavy atoms Quantity: 19


6. Surface charge :0


7. Complexity :270


8. Isotope atomic number:0


9. Determine the number of atomic stereocenters:2


10. Uncertain number of atomic stereocenters:0


11. Determine the number of stereocenters of chemical bonds:0


12. Uncertain number of chemical bond stereocenters:0


13. Number of covalent bond units: 2

Properties and stability

Stable under normal temperature and pressure.

Storage method

Seal and store in a dry and cool place.

Synthesis method

It can be obtained by extracting pilocarpine from the plant Ruta pilosa and then treating it with nitric acid.


Purpose

cholinomimetic drugs, which have the functions of miosis, lowering intraocular pressure, stimulating sweat glands and salivary gland secretion, etc., and are used to treat glaucoma .

style=”FONT: 7pt ‘Times New Roman'”> Isotope atomic number:0


9. Determine the number of atomic stereocenters:2


10. Uncertain number of atomic stereocenters:0


11. Determine the number of stereocenters of chemical bonds:0


12. Uncertain number of chemical bond stereocenters:0


13. Number of covalent bond units: 2

Properties and stability

Stable under normal temperature and pressure.

Storage method

Seal and store in a dry and cool place.

Synthesis method

It can be obtained by extracting pilocarpine from the plant Ruta pilosa and then treating it with nitric acid.


Purpose

cholinomimetic drugs, which have the functions of miosis, lowering intraocular pressure, stimulating sweat glands and salivary gland secretion, etc., and are used to treat glaucoma .

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Purpose

cholinomimetic drugs, which have the functions of miosis, lowering intraocular pressure, stimulating sweat glands and salivary gland secretion, etc., and are used to treat glaucoma .

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