lidocaine

广告位

Lidocaine structural formula

Structural formula

Business number 03RP
Molecular formula C14H22N2O
Molecular weight 234.34
label

N-diethylaminoacetyl-2,6-dimethylaniline,

xylocaine,

Xylocaine,

lidocaine base,

N-Diethylacetyl-2,6-dimethylaniline,

2-diethylamino-N-(2,6-dimethylphenyl)acetamide,

2-Diethylamino-N-(2,6-dimethylphenyl)acetamide,

Lignocaine,

Xylocaine,

aromatic compounds

Numbering system

CAS number:137-58-6

MDL number:MFCD00026733

EINECS number:205-302-8

RTECS number:AN7525000

BRN number:None

PubChem number:24896480

Physical property data

1. Appearance: white crystalline powder

2. Melting point (℃): 76~79

3. Solubility: easily soluble in water or ethanol, soluble in chloroform , insoluble in ether.

Toxicological data

None

Ecological data

None

Molecular structure data

1. Molar refractive index: 72.42

2. Molar volume (cm3/mol): 228.3

3. Isotonic specific volume (90.2K): 571.1

4. Surface tension (3.0 dyne/cm): 39.1

5. Polarizability (0.5 10-24cm3): 28.71

Compute chemical data

1. Reference value for hydrophobic parameter calculation (XlogP): None

2. Number of hydrogen bond donors: 1

3. Number of hydrogen bond acceptors: 2

4. Number of rotatable chemical bonds: 5

5. Number of tautomers: 3

6. Topological molecule polar surface area 32.3

7. Number of heavy atoms: 17

8. Surface charge: 0

9. Complexity: 228

10. Number of isotope atoms: 0

11. Determine the number of atomic stereocenters: 0

12. Uncertain number of atomic stereocenters: 0

13. Determine the number of chemical bond stereocenters: 0

14. Number of uncertain chemical bond stereocenters: 0

15. Number of covalent bond units: 1

Properties and stability

None

Storage method

This product should be sealed and stored in a cool, dry place.

Synthesis method

1. Chloroacetyl chloride method

2,6-Dimethylaniline undergoes chloroacetylation with chloroacetyl chloride, then condenses with diethylamine, and then acidifies to form a salt to obtain lidocaine.

2. Diethylaminoacetic acid methyl ester method

In the presence of sodium methoxide, 2,6-dimethylaniline and N,N-diethylaminoacetic acid methyl ester are condensed, It is then acidified to form a salt to obtain the product.

Purpose

Widely used for topical anesthesia, infiltration anesthesia, conduction anesthesia, and epidural anesthesia. It is also an important drug in the treatment of sudden arrhythmias.

广告位
This article is from the Internet, does not represent the position of Epoxy curing agent, reproduced please specify the source.https://www.dmp-30.vip/archives/96187

author:

Previous article
Next article
Contact Us

Contact us

+86 - 152 2121 6908

Online consultation: QQ交谈

E-mail: info@newtopchem.com

Working hours: Monday to Friday, 9:00-17:30, closed on holidays
Follow wechat
Scan wechat and follow us

Scan wechat and follow us

Follow Weibo
Back to top
Home
Phone
Products
Search